New research reveals that people who stop using new weight-loss injections like Wegovy and Mounjaro may regain shed pounds much more quickly than those who end traditional diet and exercise regimens.
Findings released in a prominent health publication points out that while obese people often shed substantial amounts of their body weight while using the jabs, the weight comes back at an average rate of nearly a kilo each month after stopping.
"Users purchasing such treatments must be informed of the danger of rapid rebound weight gain when the medication is stopped," cautioned lead investigator Dr. Susan Jebb.
This pace of regain means a return to starting mass within about a year and a half.
Comparing Therapies
The analysis, which examined 37 of studies involving over 9,000 of participants, contrasted the outcomes of the injectable medications with other pills.
Scientists note that individuals who shed pounds through diet and exercise generally have a slower weight regain—around 0.1 kg a month—post-intervention.
Understanding the Quick Regain
Experts suggest the way of the jabs accounts for the accelerated regain.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which controls appetite.
"Artificially providing the hormone concentrations several times higher than the body's typical production could lead to the system to generate a reduced amount of its own natural GLP-1, and could lessen sensitivity to its actions," said Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this medication results in hunger is uncontrolled, making overeating a significant risk."
An Ongoing Issue?
Medical guidelines suggest the injections for individuals with weight-linked medical conditions, alongside recommended diet and exercise modifications.
Many experts say that, considering the significant potential of relapse, the treatment might need to be life-long.
This perspective is supported by pharmaceutical companies, who note that the findings "emphasize the long-term nature of obesity," similar to managing conditions like hypertension.
Patient Experiences
People who have stopped the jabs explain a intense return of appetite.
"It felt as if a switch flipping and you become starving," described one woman.
This difficulty is exacerbated if individuals have not adopted lasting dietary or behavioural modifications during therapy.
Growing Adoption
Survey data suggest that millions of adults in the UK have used these injections in the past year, with interest continuing to grow.
- Adoption is greater among females compared to men.
- The 40s and 50s age group shows the greatest usage rates.
- A large proportion obtain the medications through private healthcare rather than public health services.
In conclusion, researchers emphasize that while GLP-1 drugs are potent tools for weight loss, they are not a magic cure and lasting health benefits likely depends on integrated lifestyle changes.
